Epidemology

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Submitted By charmbeb
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This study was undertaken with the intention of determining if the vaccine could prevent HIV infection in HIV-negative individuals; reduce the amount of virus in those who do become HIV-infected during the study, or both. The benefit of the vaccine was that if found successful it would help in preventing HIV infection and whether the vaccine and or reduce the amount of virus in those who developed an infection. I any case the research study would backfire there was a risk o the participants getting infected therefore proper awareness was made to the members and had a perfect understanding of the entire process. (White)
Throughout the trial, all participants received HIV risk-reduction counseling and various supplies, such as condoms, and information to help them avoid HIV infection. Initially, the study only enrolled individuals with low pre-existing antibodies to adenovirus type 5 (Ad 5) based on earlier indications that the vaccine would have the greatest potency for these persons; however, subsequent studies with the same vaccine lead to an amendment that opened participation to anyone who met the study’s inclusion criteria irrespective of pre-existing levels of adenovirus antibodies.
The phase 2b `test-of-concept` study was designed to test Merck’s candidate HIV vaccine MRK Ads trivalent vaccine. The study was testing Merck’s candidate vaccine, the MRKAd5 HIV-1 gag, pol, nef trivalent vaccine, which is based on a weakened adenovirus (adenovirus type 5), a common virus that normally causes upper respiratory infections, such as the common cold, but that has been altered to render it unable to replicate. The vaccine is a mixture of three weakened adenoviruses that act as vectors, or carriers, for efficiently transporting into the body and presenting to the immune system three HIV proteins: gag, pol and nef. (White)
Initially, the participants in the study were…...

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