Review of Article: “Statin Use and Risk of Cerebral Aneurysm Rupture: a Hospital-Based Case-Control Study in Japan, ” Y. Yoshimura, Y. Murakami, Et Al.

In: Other Topics

Submitted By jhfire86
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Review of article: “Statin Use and Risk of Cerebral Aneurysm Rupture: A Hospital-based Case-control Study in Japan,” Y. Yoshimura, Y. Murakami, et al.

Design and Data Collection

The presented study is a case-control study design, meaning it is based on measuring the associations between statin administration and the likely rupture of a cerebral aneurysm in purposefully selected indicator and control populations. The foundation of the study grew from theoretical components tied to animal models used in the past. The underlying conditions of interest are important but not commonly seen in humans, making it difficult to know the best medical measurements and, if possible, prescriptive interventions for unruptured neurological disorders, which generally now can be dealt with by way of surgical interventions.

The written assessment of the study indicated limited evidence of human studies showing the effect of statin drugs in reducing the risk of aneurysmal ruptures. The study model used in this investigation (case-control) is readily suitable to study uncommon diseases with low overall prevalence rates. However, given the impact such a condition could have on a population segment thought to have many years of productivity – and because of promising animal studies – the study was deemed beneficial as an initial step toward learning more about the drug’s beneficial indicators. The primary endpoint of focus was the likelihood of the rupture of an aneurism and the protective effect of statins on reducing that outcome.

According to the authors (Yoshimura, Murakami, et al), their results showed that use of any statin “was inversely associated with rupture risk in unruptured aneurysm patients.” This finding was qualified because of a number of limitations associated with their model and techniques. Our recommendation seeks to address some of these concerns.


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