Vision 2021

In: English and Literature

Submitted By jiko
Words 4984
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Available online at www.sciencedirect.com

Environmental Toxicology and Pharmacology 25 (2008) 334–341

Carbofuran in water: Subchronic toxicity to rats
Dragica V. Brki´ a , Slavoljub Lj. Vitorovi´ b , Slavica M. Gaˇi´ a , Neˇko K. Neˇkovi´ a,∗ c c sc s s c a Institute of Pesticides and Environmental Protection, Banatska 31-b,
P.O. Box 163, 11080 Belgrade, Serbia b Faculty of Agriculture, University of Belgrade, Belgrade, Serbia

Received 31 July 2007; received in revised form 26 October 2007; accepted 4 November 2007
Available online 17 November 2007

Abstract
Carbofuran toxicity on rats was studied during subchronic exposure. Female and male rats were administered carbofuran in drinking water in concentrations of 25, 100 and 400 ppm for a period of 90 days. Clinical symptoms, water consumption, body weight gain, organ weight, pathological and histopathological changes in the liver and kidneys were observed and biochemical and haematological examinations were carried out. The results obtained show that carbofuran administered to rats caused a significant decrease in water consumption as well as in brain, serum and erythrocyte cholinesterase activities. Statistically significant increases in relation to the control were found in the serum enzyme activities.
The haematological data showed that carbofuran had no significant effect on Hb concentration and total RBC, but total WBC showed a significant statistical decrease. The histopathological changes in liver and kidneys were observed. However, cell regeneration in the liver and kidneys was found in all test groups.
© 2007 Elsevier B.V. All rights reserved.
Keywords: Carbofuran; Water; Rats; Toxicity

1. Introduction
Carbofuran is a commonly used carbamate insecticide, nematicide and acaricide effective by contact, stomach and systemic action (Kuhr and Dorough, 1979; Machemer and…...

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